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  Book

Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Subject Area: Pharmacy, Medical, Dental Science
Pages: 234
Published On: 10-Nov-2025
Online Since: 10-Nov-2025

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 Book Chapter

ORAL DRUG DELIVERY: PRINCIPLES AND CHALLENGES

Author(s): Dr. Kavya B T, Dr. Vivek Bhargava, Dr. V R Balaji, Dr. Sayeeganesh Nagarajan, Dr. Amruth N Petkar

Email(s): drkavya.gdc@gmail.com , vivek.drox@gmail.com , vivek.drox@gmail.com , sayeeganesh72@gmail.com , sayeeganesh72@gmail.com

Address: Dr. Kavya B T Assistant Professor Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka. Email id: drkavya.gdc@gmail.com
Dr. Vivek Bhargava Paediatric and Preventive Dentist, Consultant and Private Practitioner, Hyderabad, Telangana. Email id: vivek.drox@gmail.com
Dr. V R Balaji MDS PhD, Professor and Head, Dept of Periodontics, CSI Dental College, Madurai, Tamil Nadu. Email id: vrbalajimds@gmail.com Dr. Sayeeganesh Nagarajan Professor, Department of Periodontol ogy, Vinayaka Mission's Sankarachariyar Dental College, VMRFDU, Salem, Tamil Nadu. Email id: sayeeganesh72@gmail.com
Dr. Amruth N Petkar Consulting Oral and Maxillofacial Surgeon, Bangalore, Karnataka. Email id: npamruth@gmail.com

Published In:   Book, Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Year of Publication:  November, 2025

Online since:  November 10, 2025

DOI: Not Available

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ABSTRACT:
Oral drug delivery remains the most preferred route for therapeutic administration due to its convenience, patient compliance, and cost-effectiveness. This review explores the fundamental principles governing oral drug delivery, including physicochemical properties of drugs, gastrointestinal physiology, and formulation strategies that influence bioavailability and therapeutic efficacy. Despite its advantages, oral delivery faces significant challenges such as enzymatic degradation, poor solubility, limited permeability, and first-pass metabolism. Advances in drug delivery technologies—such as nanoparticles, mucoadhesive systems, and targeted release formulations—offer promising solutions to overcome these barriers. A comprehensive understanding of these principles and challenges is essential for the rational design of effective oral drug delivery systems that enhance clinical outcomes and patient adherence.


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Author/Editor Information

Dr Sumit Bhatt

Assistant Professor and PhD Scholar in Oral and Maxillofacial Surgery at Rajasthan Dental College and Hospital, Nirwan University, Jaipur

Dr. Mrunal Dave

Associate dentist “Bethlehem Smile Design” Bethlehem, Pennsylvania USA.

Dr. Suyash Pratap Singh

Dr. Suyash Pratap Singh is an Endodontist and a Senior Lecturer at the Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Bareilly

Dr. S. Shruti

Dr. S. Shruti is an Associate Professor and Acting Head in the Department of Rasashastra evam Bhaishajyakalpana at Sri Ganganagar College of Ayurvedic Science and Hospital, Sri Ganganagar, Rajasthan, India