Global Research Connect Publication

We provide unique ISBN, professional Cover Design, wide Coverage and Indexing.


  Book

Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Subject Area: Pharmacy, Medical, Dental Science
Pages: 234
Published On: 10-Nov-2025
Online Since: 10-Nov-2025

 Read More >>

 Book Chapter

INNOVATIVE ORAL DRUG DELIVERY TECHNOLOGIES

Author(s): Mrs. Nityashree Mohapatra, Dr. Padmasree Patowary Saha, Dr. Priyanjit Saha, Dr. Jyoti Solanki, Sonam Soni

Email(s): nityashreerips@gmail.com , padma1792@gmail.com , mailto:priyanjit.saha1990@gmail.com , sonam.pharma16@gmail.com

Address: Mrs. Nityashree Mohapatra, Asst. Professor Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, GANJAM-760010

Dr. Padmasree Patowary Saha, Assistant Professor, Department of Oral and Maxillofacial Surgery, Kusum Devi Sundarlal Dugar Jain Dental College and Hospital, Kolkata, West Bengal

Dr. Priyanjit Saha, Assistant Professor, Department of Conservative Dentistry & Endodontics, Kusum Devi Sundarlal Dugar Jain Dental College and Hospital, Kolkata, West Bengal

Dr. Jyoti Solanki, Senior Resident, Department of Dentistry, Mahamaya Rajkiya Allopathic Medical College, Ambedkarnagar, Uttar Pradesh – 224190

Sonam Soni, Associate Professor, Chhattisgarh swami vivekanand technical, university bhilai newai

Published In:   Book, Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Year of Publication:  November, 2025

Online since:  November 10, 2025

DOI: Not Available

 View HTML        View PDF

ABSTRACT:
Innovative oral drug delivery technologies are transforming the landscape of pharmaceutical therapeutics by addressing limitations of conventional oral formulations. These advancements aim to enhance bioavailability, control drug release, and improve patient adherence. Emerging strategies include the use of nanocarriers, mucoadhesive systems, gastroretentive platforms, and stimuli-responsive formulations that overcome physiological barriers such as enzymatic degradation and first-pass metabolism. Technologies like 3D printing, microencapsulation, and lipid-based carriers further enable precision dosing and targeted delivery. This review highlights the principles, mechanisms, and clinical relevance of these novel approaches, underscoring their potential to revolutionize oral pharmacotherapy and expand the scope of treatable conditions via the oral route.


Keywords:

Cite this article:
working


REFERENCES

1.     Agüero, L., Zaldivar-Silva, D., Peña, L., & Dias, M. L. (2017). Alginate microparticles as oral colon drug delivery device: A review. Carbohydrate polymers, 168, 32-43.

2.     Alqahtani, M. S., Kazi, M., Alsenaidy, M. A., & Ahmad, M. Z. (2021). Advances in oral drug delivery. Frontiers in pharmacology, 12, 618411.

3.     Ezike, T. C., Okpala, U. S., Onoja, U. L., Nwike, C. P., Ezeako, E. C., Okpara, O. J., ... & Nwanguma, B. C. (2023). Advances in drug delivery systems, challenges and future directions. Heliyon, 9(6).

4.     Goyanes, A., Det-Amornrat, U., Wang, J., Basit, A. W., & Gaisford, S. (2016). 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. Journal of controlled release, 234, 41-48.

5.     Homayun, B., Lin, X., & Choi, H. J. (2019). Challenges and recent progress in oral drug delivery systems for biopharmaceuticals. Pharmaceutics, 11(3), 129.

6.     Hua, S. (2020). Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors. Frontiers in pharmacology, 11, 524.

7.     Irfan, M., Rabel, S., Bukhtar, Q., Qadir, M. I., Jabeen, F., & Khan, A. (2016). Orally disintegrating films: A modern expansion in drug delivery system. Saudi pharmaceutical journal, 24(5), 537-546.

8.     Jain, K. K. (2019). An overview of drug delivery systems. Drug delivery systems, 1-54.

9.     Jain, S. K., Sahu, A., & Keservani, R. K. (2023). Oral drug delivery system: An overview on recent advances in novel drug delivery system. Advances in Novel Formulations for Drug Delivery, 383-400.

10.  Kalepu, S., & Nekkanti, V. (2015). Insoluble drug delivery strategies: review of recent advances and business prospects. Acta Pharmaceutica Sinica B, 5(5), 442-453.

11.  Karki, S., Kim, H., Na, S. J., Shin, D., Jo, K., & Lee, J. (2016). Thin films as an emerging platform for drug delivery. asian journal of pharmaceutical sciences, 11(5), 559-574.

12.  Kirtane, A. R., Abouzid, O., Minahan, D., Bensel, T., Hill, A. L., Selinger, C., ... & Traverso, G. (2018). Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy. Nature communications, 9(1), 2.

13.  Marwah, H., Garg, T., Goyal, A. K., & Rath, G. (2016). Permeation enhancer strategies in transdermal drug delivery. Drug delivery, 23(2), 564-578.

14.  Misra, A., & Shahiwala, A. (2019). Novel drug delivery technologies. Springer: Berlin/Heidelberg, Germany.

15.  Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodriguez-Torres, M. D. P., Acosta-Torres, L. S., ... & Shin, H. S. (2018). Nano based drug delivery systems: recent developments and future prospects. Journal of nanobiotechnology, 16(1), 71.

16.  Tibbitt, M. W., Dahlman, J. E., & Langer, R. (2016). Emerging frontiers in drug delivery. Journal of the American Chemical Society, 138(3), 704-717.

17.  Vazzana, M., Andreani, T., Fangueiro, J., Faggio, C., Silva, C., Santini, A., ... & Souto, E. B. (2015). Tramadol hydrochloride: pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomed Pharmacother, 70(234), 8.

18.  Yun, Y. H., Lee, B. K., & Park, K. (2015). Controlled Drug Delivery: Historical perspective for the next generation. Journal of Controlled Release, 219, 2-7.

19.  Zaid Alkilani, A., McCrudden, M. T., & Donnelly, R. F. (2015). Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics, 7(4), 438-470.

20.  Zylberberg, C., & Matosevic, S. (2016). Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Drug delivery, 23(9), 3319-3329.




Author/Editor Information

Dr Sumit Bhatt

Assistant Professor and PhD Scholar in Oral and Maxillofacial Surgery at Rajasthan Dental College and Hospital, Nirwan University, Jaipur

Dr. Mrunal Dave

Associate dentist “Bethlehem Smile Design” Bethlehem, Pennsylvania USA.

Dr. Suyash Pratap Singh

Dr. Suyash Pratap Singh is an Endodontist and a Senior Lecturer at the Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Bareilly

Dr. S. Shruti

Dr. S. Shruti is an Associate Professor and Acting Head in the Department of Rasashastra evam Bhaishajyakalpana at Sri Ganganagar College of Ayurvedic Science and Hospital, Sri Ganganagar, Rajasthan, India