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  Book

Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Subject Area: Pharmacy, Medical, Dental Science
Pages: 234
Published On: 10-Nov-2025
Online Since: 10-Nov-2025

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 Book Chapter

TRANSDERMAL DRUG DELIVERY SYSTEMS: BASIC CONCEPTS

Author(s): Ranjna Rani, S.Gopi Krishnan, Meghana Milind Gore, Sonam Soni, Dr. Ritesh Kumar

Email(s): ranirathi19@gmail.com , ranirathi19@gmail.com , meghanagore101@gmail.com , sonam.pharma16@gmail.com , ritesh.kumar@agra.sharda.ac.in

Address: Ranjna Rani Assistant Professor Institute address - Geeta Institute of Pharmacy, Geeta University, Naultha, Panipat, Pin 132145
S.Gopi Krishnan Associate Professor Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnakoil, Tamilnadu, 626 126
Meghana Milind Gore Assistant professor Institute address: B.K. Patil Institute of Pharmacy, Taloja, Navi Mumbai Plot no. 73, Sec 17 Taloja Phase 2, Navi Mumbai 410208
Sonam Soni Associate Professor Institute address: Chhattisgarh Swami Vivekanand Technical University Bhilai Newai
Dr. Ritesh Kumar Associate Professor Institute address- Sharda School of Pharmacy, Sharda University Agra, Agra, Uttar Pradesh, India, Pin- 282007

Published In:   Book, Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Year of Publication:  November, 2025

Online since:  November 10, 2025

DOI: Not Available

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ABSTRACT:
Transdermal Drug Delivery Systems are designed to deliver therapeutic agents across the skin barrier into systemic circulation. These systems offer several advantages, including bypassing first-pass metabolism, maintaining steady plasma drug levels, and improving patient compliance. 🔍 Key Principles • Skin as a Barrier: The stratum corneum, the outermost layer of the skin, is the primary barrier to drug permeation. Only small, lipophilic, and low molecular weight drugs can passively diffuse through it. • Mechanism: Drugs are released from a patch or formulation and diffuse through the epidermis and dermis into the capillary network. • Rate-Controlled Delivery: TDDS can be designed to release drugs at a controlled rate, ensuring prolonged therapeutic effect. 🧪 Types of TDDS • Reservoir Systems: Contain a drug reservoir with a rate-controlling membrane. • Matrix Systems: Drug is dispersed in a polymer matrix that controls release. • Adhesive Dispersion Systems: Drug is incorporated directly into the adhesive layer. ⚙️ Enhancement Techniques • Chemical Enhancers: Disrupt the lipid structure of the stratum corneum. • Physical Methods: Include iontophoresis, microneedles, sonophoresis, and thermal ablation to increase permeability. • Vesicular Carriers: Liposomes and ethosomes improve drug solubility and penetration.


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REFERENCES

1.     Alkilani, A. Z., Nasereddin, J., Hamed, R., Nimrawi, S., Hussein, G., Abo-Zour, H., & Donnelly, R. F. (2022). Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems. Pharmaceutics, 14(6), 1152.

2.     Ashtikar, M., Nagarsekar, K., & Fahr, A. (2016). Transdermal delivery from liposomal formulations–Evolution of the technology over the last three decades. Journal of Controlled Release, 242, 126-140.

3.     Chauhan, I., Yasir, M., Verma, M., & Singh, A. P. (2020). Nanostructured lipid carriers: A groundbreaking approach for transdermal drug delivery. Advanced pharmaceutical bulletin, 10(2), 150.

4.     Devarajan, P. V., & Jain, S. (Eds.). (2015). Targeted drug delivery: concepts and design.

5.     Economidou, S. N., Lamprou, D. A., & Douroumis, D. (2018). 3D printing applications for transdermal drug delivery. International journal of pharmaceutics, 544(2), 415-424.

6.     Jain, K. K. (2019). An overview of drug delivery systems. Drug delivery systems, 1-54.

7.     Jeong, W. Y., Kwon, M., Choi, H. E., & Kim, K. S. (2021). Recent advances in transdermal drug delivery systems: A review. Biomaterials research, 25(1), 24.

8.     Kumar, V., Praveen, N., Kewlani, P., Arvind, Singh, A., Gautam, A. K., & Mahalingam Rajamanickam, V. (2023). Transdermal drug delivery systems. In Advanced Drug Delivery: Methods and Applications (pp. 333-362). Singapore: Springer Nature Singapore.

9.     Maiti, S., & Sen, K. K. (2017). Introductory chapter: Drug delivery concepts. In Advanced technology for delivering therapeutics. IntechOpen.

10.  Matharoo, N., Mohd, H., & Michniak‐Kohn, B. (2024). Transferosomes as a transdermal drug delivery system: Dermal kinetics and recent developments. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 16(1), e1918.

11.  Mishra, B., & Bonde, G. V. (2020). Transdermal drug delivery. In Controlled drug delivery systems (pp. 239-275). CRC Press.

12.  Ng, L. C., & Gupta, M. (2020). Transdermal drug delivery systems in diabetes management: A review. Asian journal of pharmaceutical sciences, 15(1), 13-25.

13.  Opatha, S. A. T., Titapiwatanakun, V., & Chutoprapat, R. (2020). Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics, 12(9), 855.

14.  Phatale, V., Vaiphei, K. K., Jha, S., Patil, D., Agrawal, M., & Alexander, A. (2022). Overcoming skin barriers through advanced transdermal drug delivery approaches. Journal of controlled release, 351, 361-380.

15.  Rabiei, M., Kashanian, S., Samavati, S. S., Jamasb, S., & McInnes, S. J. (2020). Nanomaterial and advanced technologies in transdermal drug delivery. Journal of drug targeting, 28(4), 356-367.




Author/Editor Information

Dr Sumit Bhatt

Assistant Professor and PhD Scholar in Oral and Maxillofacial Surgery at Rajasthan Dental College and Hospital, Nirwan University, Jaipur

Dr. Mrunal Dave

Associate dentist “Bethlehem Smile Design” Bethlehem, Pennsylvania USA.

Dr. Suyash Pratap Singh

Dr. Suyash Pratap Singh is an Endodontist and a Senior Lecturer at the Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Bareilly

Dr. S. Shruti

Dr. S. Shruti is an Associate Professor and Acting Head in the Department of Rasashastra evam Bhaishajyakalpana at Sri Ganganagar College of Ayurvedic Science and Hospital, Sri Ganganagar, Rajasthan, India