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  Book

Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Subject Area: Pharmacy, Medical, Dental Science
Pages: 234
Published On: 10-Nov-2025
Online Since: 10-Nov-2025

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 Book Chapter

MODERN INNOVATIONS IN TRANSDERMAL DELIVERY

Author(s): Dr Arpan Kumar Tripathi

Email(s): arpan260387@gmail.com

Address: Dr. Arpan Kumar Tripathi Associate Professor KIPS, SSPU Bhilai, Chhattisgarh, India

Published In:   Book, Innovations in Oral, Injectable, and Transdermal Drug Delivery Systems

Year of Publication:  November, 2025

Online since:  November 10, 2025

DOI: Not Available

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ABSTRACT:
Transdermal Drug Delivery Systems (TDDS) have emerged as a transformative approach for non-invasive, sustained, and controlled drug administration through the skin. Recent innovations aim to overcome the formidable barrier posed by the stratum corneum, enabling efficient delivery of both small and large molecules. Advanced strategies include microneedle arrays, iontophoresis, sonophoresis, and chemical enhancers, which facilitate deeper skin penetration without compromising safety. Nanotechnology-based carriers—such as liposomes, ethosomes, and solid lipid nanoparticles—offer targeted delivery, improved bioavailability, and reduced systemic side effects. Bioinspired and biomimetic systems, mimicking natural transport mechanisms, further enhance drug permeation and retention. These innovations also support the delivery of biologics, peptides, and vaccines, expanding the therapeutic scope of TDDS. Despite promising outcomes, challenges remain in scalability, regulatory approval, and long-term safety. Future perspectives emphasize personalized transdermal platforms, integration with wearable sensors, and smart delivery systems responsive to physiological cues.


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Sahu, A., Mishra, S., Wal, P., Debnath, B., Chouhan, D., Gunjal, S. D., & Tripathi, A. K. (2024). Novel Quinoline‐Based RAF Inhibitors: A Comprehensive Review on Synthesis, SAR and Molecular Docking Studies. ChemistrySelect, 9(23), e202400347.

2.     Tripathi, A. K., Soni, R., & Verma, S. (2022). A review on ethnopharmacological applications, pharmacological activities, and bioactive compounds of Mimosa pudica (linn.). Research Journal of Pharmacy and Technology, 15(9), 4293-4299.

3.     Sinha, S., Tripathi, A. K., Pandey, A., Naik, P., Pandey, A., & Verma, V. S. (2024). Self-assembled PEGylated micelles for precise and targeted drug delivery: Current challenges and future directions. Biocatalysis and Agricultural Biotechnology, 60, 103296.

4.     Mishra, S., Grewal, J., Wal, P., Bhivshet, G. U., Tripathi, A. K., & Walia, V. (2024). Therapeutic potential of vasopressin in the treatment of neurological disorders. Peptides, 174, 171166.

5.     Koliqi, R., Fathima, A., Tripathi, A. K., Sohi, N., Jesudasan, R. E., & Mahapatra, C. (2023). Innovative and Effective Machine Learning-Based Method to Analyze Alcoholic Brain Activity with Nonlinear Dynamics and Electroencephalography Data. SN Computer Science, 5(1), 113.

6.     Tripathi, A. K., Dwivedi, C. P., Bansal, P., Pradhan, D. K., Parganiha, R., & Sahu, D. (2022). An Ethnoveterinary Important Plant Terminalia Arjuna. International Journal of Health Sciences, (II), 10601-10607.

7.     Habeeb, M., Vengateswaran, H. T., Tripathi, A. K., Kumbhar, S. T., You, H. W., & Hariyadi. (2024). Enhancing biomedical imaging: the role of nanoparticle-based contrast agents. Biomedical Microdevices, 26(4), 42.

8.     Singh, K., Jain, D., Sethi, P., Gupta, J. K., Tripathi, A. K., Kumar, S., ... & Guru, A. (2024). Emerging pharmacological approaches for Huntington's disease. European Journal of Pharmacology, 980, 176873.

9.     Babbar, R., Kaur, A., Vanya, Arora, R., Gupta, J. K., Wal, P., ... & Behl, T. (2024). Impact of bioactive compounds in the management of various inflammatory diseases. Current Pharmaceutical Design, 30(24), 1880-1893.

10.  Tripathi, A. K., Sharma, N., Mishra, J., Bisoi, D., Mohapatra, N., Muztaba, M. M., ... & TarakaRamarao, C. (2023). Evaluation Of Anti–Inflammatory Activity Of Plant Extract Of Cordia Dichotoma Leaves On Carrageenan-Induced Paw Edema In Albino Wister Rats And Its Phytochemical Analysis. Ann. For. Res, 66(1), 803-818.

11.  Gupta, J., Kumar, D., Gupta, R., Diwakar, D., Shanno, K., Tripathi, A. K., ... & Kumar, M. (2025). Therapeutic Potential of Traditional Chinese Medicine loaded Nanocarriers in Wound Management: Current Status and their Future Perspective. Pharmacological Research-Modern Chinese Medicine, 100622.

12.  Tripathi, A. K. Toxicity Evaluation of Textile Effluents on Gill Morphology and Enzyme Activity in Zebrafish.

13.  Singh, B., Mahmood, A. A. R., Semwal, B. C., Dewangan, H. K., Alam, P., & Tripathi, A. K. (2025). Encapsulation of lysozyme in hybrid vesicles to protect from thermal challenges. International Journal of Biological Macromolecules, 312, 143603.

14.  Prabagar, J. S., Ashajyothi, C., Tripathi, A. K., Makgwane, P. R., Rasool, A., Alqarni, M. H., ... & Shivaraju, H. P. (2025). Synergistic effects of Ag/gC 3 N 4-incorporated bi-metallic ZnTi-LDH in CO 2 photoreduction to hydrocarbons. Materials Advances.

15.  Raj, R., Tripathi, A. K., Saranya, P., Pal, R. S., Singh, K., Jain, D., ... & Kumar, S. (2024). A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis. Pharmacological Research-Modern Chinese Medicine, 13, 100521.

16.  Tripathi, A. K. A text book of pathophysiology. NEXUS KNOWLEDGE PUBLICATION.

17.  Dwivedi, J., Wal, P., Wagh, V. D., Sachan, P., Joshi, N. S., Goyal, S., & Tripathi, A. K. (2025). Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches. Combinatorial Chemistry & High Throughput Screening.

18.  Kapil, P., Tripathi, A. K., Pal, R. S., Singh, S. K., Singh, K., Jain, D., & Chaitanya, M. V. N. L. (2025). Therapeutic Potential of Plant Phenolic Acids Combating Cancer Drug Resistance. Recent Advances in Food, Nutrition & Agriculture.




Author/Editor Information

Dr Sumit Bhatt

Assistant Professor and PhD Scholar in Oral and Maxillofacial Surgery at Rajasthan Dental College and Hospital, Nirwan University, Jaipur

Dr. Mrunal Dave

Associate dentist “Bethlehem Smile Design” Bethlehem, Pennsylvania USA.

Dr. Suyash Pratap Singh

Dr. Suyash Pratap Singh is an Endodontist and a Senior Lecturer at the Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Bareilly

Dr. S. Shruti

Dr. S. Shruti is an Associate Professor and Acting Head in the Department of Rasashastra evam Bhaishajyakalpana at Sri Ganganagar College of Ayurvedic Science and Hospital, Sri Ganganagar, Rajasthan, India